Baodong Sun Selected Research

Enzyme Replacement Therapy

1/2018	Therapeutic Benefit of Autophagy Modulation in Pompe Disease.
12/2017	A pilot study on using rapamycin-carrying synthetic vaccine particles (SVP) in conjunction with enzyme replacement therapy to induce immune tolerance in Pompe disease.
1/2017	Antibody-mediated enzyme replacement therapy targeting both lysosomal and cytoplasmic glycogen in Pompe disease.
1/2017	Alglucosidase alfa enzyme replacement therapy as a therapeutic approach for a patient presenting with a PRKAG2 mutation.
1/2014	Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease.
2/2013	Alglucosidase alfa enzyme replacement therapy as a therapeutic approach for glycogen storage disease type III.
1/2013	Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease.
5/2012	Immunodominant liver-specific expression suppresses transgene-directed immune responses in murine pompe disease.
6/2011	Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle.
2/2010	Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease.

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Baodong Sun Research Topics

Disease

27	Glycogen Storage Disease Type II (Pompe's Disease) 07/2023 - 04/2003
6	Glycogen Storage Disease (Glycogenosis) 07/2023 - 11/2012
6	Glycogen Storage Disease IIIA 12/2022 - 11/2012
5	Liver Cirrhosis (Hepatic Cirrhosis) 12/2022 - 06/2014
5	Neoplasms (Cancer) 12/2021 - 02/2002
4	Carcinoma (Carcinomatosis) 07/2023 - 02/2002
4	Glycogen Storage Disease Type III (Cori's Disease) 12/2022 - 02/2013
3	Hypoglycemia (Reactive Hypoglycemia) 07/2023 - 08/2009
3	Fibrosis (Cirrhosis) 09/2020 - 11/2012
3	Glycogen Storage Disease Type IV (Andersen's Disease) 01/2017 - 01/2016
2	Muscular Diseases (Myopathy) 07/2023 - 06/2014
2	Adenoma (Adenomas) 07/2023 - 08/2009
2	Cardiomyopathies (Cardiomyopathy) 07/2023 - 11/2007
2	Glycogen Storage Disease Type I 07/2023 - 08/2009
2	Body Weight (Weight, Body) 01/2021 - 12/2016
2	Disease Progression 01/2021 - 02/2016
2	Muscle Weakness 01/2017 - 11/2005
2	Liver Diseases (Liver Disease) 12/2016 - 02/2016
2	Hepatorenal form of glycogen storage disease 08/2009 - 04/2008
1	Chronic Kidney Failure (Chronic Renal Failure) 07/2023
1	Glycogen Storage Disease Type Ix 01/2021
1	Gout 01/2021
1	Inflammation (Inflammations) 01/2021
1	Hyperuricemia 01/2021
1	Chronic Renal Insufficiency 01/2021
1	Carcinogenesis 09/2020
1	Thymoma (Thymic Carcinoma) 09/2020
1	Muscular Atrophy (Muscle Atrophy) 01/2018
1	Atrophy 01/2018
1	Osteoarthritis 01/2017
1	Muscle Hypotonia (Hypotonia) 01/2017
1	Weight Gain 06/2013
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 03/2012
1	Hepatocellular Carcinoma (Hepatoma) 08/2009
1	Renal Insufficiency (Renal Failure) 08/2009
1	Muscular Dystrophies (Muscular Dystrophy) 12/2006

Drug/Important Bio-Agent (IBA)

22	GlycogenIBA 07/2023 - 01/2005
19	AcidsIBA 10/2019 - 04/2003
13	EnzymesIBA 07/2023 - 12/2006
11	alpha-Glucosidases (Acid Maltase)IBA 07/2019 - 04/2003
9	GlucosidasesIBA 10/2019 - 11/2010
7	human GAA protein (Myozyme)FDA Link 12/2017 - 02/2010
4	Biomarkers (Surrogate Marker)IBA 12/2022 - 01/2005
3	Liver GlycogenIBA 09/2020 - 11/2012
3	Glycogen Debranching Enzyme System (Glycogen Debranching Enzyme)IBA 09/2020 - 11/2012
3	Proteins (Proteins, Gene)FDA Link 09/2020 - 03/2012
3	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 10/2019 - 04/2008
3	Sirolimus (Rapamycin)FDA Link 12/2017 - 06/2014
3	IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA 01/2013 - 11/2010
2	Glucose (Dextrose)FDA LinkGeneric 07/2023 - 04/2008
2	Creatine Kinase (Creatine Phosphokinase)IBA 12/2022 - 02/2016
2	pullulanase (limit dextrinase)IBA 12/2022 - 09/2020
2	AntibodiesIBA 12/2017 - 02/2010
2	polyglucosanIBA 01/2017 - 01/2016
2	1,4-alpha-Glucan Branching Enzyme (Glycogen Branching Enzyme)IBA 01/2017 - 01/2016
2	AN 238IBA 02/2002 - 02/2002
2	RC 121IBA 02/2002 - 02/2002
2	AN 204 (AN 201)IBA 02/2002 - 02/2002
2	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 02/2002 - 02/2002
1	Bortezomib (Velcade)FDA Link 01/2023
1	Neutralizing AntibodiesIBA 01/2023
1	Alanine Transaminase (SGPT)IBA 12/2022
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 12/2022
1	FlavonoidsIBA 12/2021
1	LuteolinIBA 12/2021
1	Anti-Allergic Agents (Antiallergic Agents)IBA 12/2021
1	Uric Acid (Urate)IBA 01/2021
1	C-Reactive ProteinIBA 01/2021
1	CreatinineIBA 01/2021
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2021
1	Hematoxylin (Haematoxylon)IBA 01/2021
1	Triglycerides (Triacylglycerol)IBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Interleukin-18 (Interleukin 18)IBA 01/2021
1	Complementary DNA (cDNA)IBA 09/2020
1	DextrinsIBA 09/2020
1	TOR Serine-Threonine KinasesIBA 09/2020
1	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 09/2020
1	trans-sodium crocetinate (crocetin)IBA 01/2018
1	Ubiquitinated ProteinsIBA 01/2018
1	Synthetic Vaccines (Recombinant Vaccines)IBA 12/2017
1	CytokinesIBA 01/2017
1	Polysaccharides (Glycans)IBA 01/2016
1	Glycogen Synthase (Synthase I)IBA 06/2014
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 06/2014
1	Monoclonal AntibodiesIBA 01/2014
1	Growth Hormone (Somatotropin)IBA 06/2013
1	Insulin-Like PeptidesIBA 06/2013
1	CationsIBA 01/2013
1	ProteomeIBA 03/2012
1	Dyneins (Dynein)IBA 08/2011
1	Doxycycline (Periostat)FDA LinkGeneric 08/2011
1	ClenbuterolIBA 06/2011
1	mannose-6-phosphateIBA 11/2010
1	Immunoglobulin G (IgG)IBA 02/2010
1	Immunoglobulin E (IgE)IBA 02/2010

Therapy/Procedure

11	Enzyme Replacement Therapy 01/2018 - 11/2007
10	Therapeutics 07/2023 - 02/2002
2	Intravenous Injections 09/2020 - 03/2019
1	Mechanical Ventilators (Ventilator) 11/2007